| Group | Club/Team Name | Team ID | Head Coach |
| Seed 1 | Florence Soccer Association - 01 FSA 04 Girls |
03043-0011G8U-0004 | Callie Mills |
| Seed 2 | South Carolina United FC - Competitive SCUFC 04 Girls Classic |
02208-2081G8U-0464 | Eric Navarro |
| Seed 3 | Charleston United SC - 01 Charleston United '04/05 Girls Blue |
03002-0011G8U-0063 | Mike Jackson |
| Seed 4 | Hartsville United Soccer League - 01 Hartsville United Girls U17 |
02229-001C1G8U-0004 | Zachary Davis |